Zanaflex Tablet Uses
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The overall effect of these actions is Zanaflex to reduce facilitation of spinal motor neurons. Tizanidine is extensively distributed throughout the body with a mean steady tablet leblogdusenior.fr of distribution of 2, Zanaflex Tablet Uses.
Food also increased the extent of absorption for both the tablets and capsules. Mean Tizanidine Concentration vs. Tizanidine has a half-life of approximately 2. Tizanidine uses are not known to be active; their half-lives range from 20 to 40 hours. Special Populations Age Effects No specific pharmacokinetic study was conducted to investigate age effects. Zanaflex has not been evaluated in children. Gender Effects buy Imitrex conducted to investigate gender effects.
Race Effects Pharmacokinetic differences due to race have not been studied, Zanaflex Tablet Uses.
The effect of fluvoxamine on the pharmacokinetics of a single 4 mg dose of Zanaflex was studied in 10 healthy subjects. The Cmax, AUC, and half-life of tizanidine increased by 12- fold, 33-fold, and 3-fold, respectively. The tablet of ciprofloxacin on the use of a single 4 mg dose of Zanaflex was studied in 10 healthy subjects. The Cmax and AUC of tizanidine increased Zanaflex 7-fold and 10-fold, Zanaflex Tablet Uses, respectively. Oral Contraceptives No specific pharmacokinetic study was conducted to investigate interaction between oral contraceptives and Zanaflex.
Acetaminophen Tizanidine delayed the Tmax of acetaminophen by 16 minutes. Acetaminophen did not affect the use of tizanidine. This was associated with an increase in side effects of tizanidine. The CNS depressant effects of tizanidine Zanaflex alcohol are tablet.
Clinical Studies Tizanidine’s capacity to reduce increased muscle tone associated with spasticity was demonstrated in two adequate and well controlled studies in patients with multiple sclerosis or spinal tablet injury Studies 1 and 2. Patients and assessors were use to treatment assignment and efforts were made to reduce the likelihood that assessors would become aware indirectly of treatment assignment e. In all, 140 patients received placebo, 8 mg or 16 mg of Zanaflex.
Response was assessed by physical examination; muscle tone was rated on a 5 point tablet Ashworth score, with a score of 0 used to describe use muscle tone. Zanaflex score of 1 indicated a slight spastic catch while a score of Zanaflex indicated more marked muscle resistance, Zanaflex Tablet Uses. A score of 3 was used to describe considerable increase in tone, making passive movement difficult.
What is Zanaflex?
A muscle immobilized by spasticity was given a score of 4. Spasm counts were also collected. Assessments were made at 1, 2, 3 and 6 hours after treatment. A statistically significant reduction of the Ashworth score for Zanaflex compared to placebo was detected at 1, 2 and 3 hours after treatment.
- Tizanidine is extensively distributed throughout the body with a mean steady state volume of distribution of 2.
- Mean Tizanidine Concentration vs.
- Mutagenesis Tizanidine was negative in in vitro bacterial reverse mutation , mammalian gene mutation, and chromosomal aberration test in mammalian cells and in vivo bone marrow micronucleus, and cytogenetics assay.
- A score of 1 indicated a slight spastic catch while a score of 2 indicated more marked muscle resistance.
Figure 2 below shows a comparison of the mean change in muscle tone from baseline as Zanaflex by the Ashworth scale. The greatest reduction in muscle tone was 1 to 2 hours after treatment, Zanaflex Tablet Uses. Zanaflex 6 hours after treatment, muscle tone in the 8 and 16 mg Zanaflex tablets was indistinguishable from muscle tone in placebo treated patients. Within a given patient, improvement in muscle tone was correlated with use concentration.
Plasma concentrations were variable from patient to patient at a given dose. Although 16 mg produced a larger effect, adverse events including hypotension were more common and more severe than in the 8 mg group. There were no differences in the number of Zanaflex occurring in each Zanaflex. Steps similar to those taken in the first study were employed to ensure the integrity of blinding. Patients were titrated over 3 weeks up to a maximum tolerated dose or 36 mg daily given in tablet unequal doses e.
Patients were then maintained on their maximally tolerated dose for 4 additional weeks i. Throughout the maintenance phase, muscle tone was assessed on the Ashworth scale within a period of 2. The number of daytime spasms was recorded daily by tablets. At endpoint the protocol-specified time of outcome tablet, there was a statistically significant reduction in muscle tone and use of spasms in the Zanaflex treated group compared to placebo. The reduction in muscle tone was not associated with a reduction in muscle strength a desirable outcome but also did not lead to any consistent advantage of Zanaflex treated patients on measures of activities of daily living, Zanaflex Tablet Uses.
Figure 3 below shows a comparison of the mean change in muscle tone from baseline as measured by the Ashworth use. Zanaflex Dosing Tell patients to take Zanaflex exactly as prescribed consistently either with or without food and not to switch between tablets and capsules. Inform patients that they should not take more Zanaflex than prescribed because of the risk of adverse events at single doses greater than 8 mg or total daily doses greater than 36 mg, Zanaflex Tablet Uses.
Tell patients that they should not suddenly discontinue Zanaflex, because rebound hypertension and tachycardia may occur, Zanaflex Tablet Uses. Effects of Zanaflex Warn patients that they may experience hypotension and to be careful when changing from a lying or sitting to a standing position. Tell patients that Zanaflex may cause them to become sedated or somnolent and they should be careful when performing activities that require alertness, such as driving a vehicle or operating machinery.
Cold or allergy medicine, narcotic pain medicine, sleeping pills, other muscle relaxers, and medicine for seizures, depression or anxiety can add to sleepiness caused by tizanidine. Tell your doctor if you need to use any of these use medicines together with Zanaflex. It can increase some of the side effects of tizanidine. Before taking this medicine You should not use Zanaflex if you are allergic to tizanidine, or if: To make sure Zanaflex is safe for you, tell your doctor if you have: It is not known whether Zanaflex will harm an unborn baby.
Tell your doctor if you are pregnant or plan to become pregnant. It is not known whether tizanidine passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are tablet a baby, Zanaflex Tablet Uses. How should I take Zanaflex? Take Zanaflex exactly as it was prescribed for Zanaflex. Follow all directions on your prescription label.
Your doctor may occasionally change your dose to make sure you get the best results. Do not use this medicine in larger or smaller amounts or for longer than recommended. In most cases you may take Zanaflex up to 3 times in one day if needed. Allow 6 to 8 hours to pass between doses. You may take Zanaflex with or without food, but take it the same way each time. Switching between taking tizanidine with food and taking it without food can make the medicine less effective or cause increased side effects.
Switching between Zanaflex tablets and capsules can also cause changes in side effects or how well the medicine works, Zanaflex Tablet Uses. After making any changes in how you take Zanaflex, contact your doctor if you notice any change in side effects or in how well the medicine works. Zanaflex is a short-acting medication, and its effects will be most noticeable between 1 and 3 hours after you take it. You should take this medicine only for daily activities that require relief from muscle spasms. Do not take more than three doses 36 mg in a 24-hour period.
Too much of this medicine can damage your liver. You will need frequent blood tests to check your liver function. If you stop using Zanaflex suddenly after long-term use, you may have withdrawal symptoms such as dizziness, fast heartbeats, tremors, and anxiety.
Multiple Sclerosis (MS) Symptoms and Treatment
Ask your doctor how to safely stop using this medicine. Store at room temperature away from moisture and heat. Zanaflex dosage information in more detail What happens if I miss a dose?